About Oestrogel (estradiol-17β)

Oestrogel is a form of oestrogen-only hormone replacement therapy (HRT). It may be used by women who have a uterus, or by women who do not have a uterus (i.e. have had a hysterectomy). For women with a uterus, your doctor is likely to also prescribe a progestogen alongside the oestrogen treatment. Talk to your doctor for more information.

Oestrogel contains the active ingredient 17β – oestradiol, which is identical in structure to that produced by your body and often referred to as body-identical oestrogen.

The 17β – oestradiol in Oestrogel is derived from plants.

Oestrogel is a colourless gel that is applied to the skin (known as transdermal application), and the active ingredient is absorbed through the skin into the bloodstream.

What is Oestrogel used for?

Relief of symptoms occurring after menopause

During the menopause, the amount of the oestrogen produced by a woman’s body drops. This can cause symptoms such as hot face, neck and chest (“hot flushes”). Oestrogel alleviates these symptoms after menopause. You will only be prescribed Oestrogel if your symptoms seriously hinder your daily life.

Prevention of osteoporosis (2nd line)

After the menopause some women may develop fragile bones (osteoporosis). You should discuss all available options with your doctor. If you are at an increased risk of fractures due to osteoporosis and other medicines are not suitable for you, you can use Oestrogel to prevent osteoporosis after menopause.


It is recommended that you have an appointment with your doctor to review your treatment after 3 months of using HRT, to check how well it is working and how your body is responding. After which, an annual appointment may be sufficient, unless you experience any problems with your treatment in which case you should consult your doctor straight away.

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